For an oocyte to generally be ready for fertilization and advancement into an embryo, the proper set of genes must be turned on. Namekawa suspected that this pre-programming from the oocyte genome takes place in a number of stages — the first 1 setting up across the time a female is born. He thought that chromatin remodeling proteins did much of the do the job, by shifting spools all around.
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Munakata and Namekawa will Review mice with ordinary and mutated versions with the chromatin remodeler. Because the mice improve and experienced, they are going to notice whether the existence or absence of the protein triggers dissimilarities while in the arrangement of DNA spools within the animals’ oocytes. And they'll keep an eye on irrespective of whether this, subsequently, alters the sample of gene expression with time.
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This protein could “create and preserve the chromatin condition,” says Namekawa — preserving the spools in position plus the oocytes genetically primed since the mouse matures.
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